If an opioid analgesic is initiated in the client now using a benzodiazepine or CNS depressant: A decreased First dose with the opioid analgesic is recommended; titrate determined by clinical reaction.CYP450 3A4 Interaction: The concomitant use with CYP450 3A4 inhibitors (or discontinuation of CYP450 3A4 inducers) may well end in a fatal overdose o